Adverse effect

Thyrotropin receptor

Endocrinology

Receptor

Immunology

Autoantibody

Triiodothyronine

Immune system

Antigen

Internal medicine

Hormone

Tolerability

Medicine

Immunotherapy

Antibody

Cancer

Graves' disease

Thyroid

Graves' disease is one of the most common autoimmune conditions, but treatment remains imperfect. This study explores the first-in-human use of antigen-specific immunotherapy with a combination of two thyrotropin receptor (TSHR) peptides (termed ATX-GD-59) in Graves' hyperthyroidism.

Antigen-Specific Immunotherapy with Thyrotropin Receptor Peptides in Graves' Hyperthyroidism: A Phase I Study