Original paper
T-cell activation and HLA-regulated response to smoking in the deep airways of patients with multiple sclerosis
Abstract
Cigarette smoking is a risk factor for multiple sclerosis (MS), and the risk is further multiplied for HLA-DRB1*15(+) smokers. To define the smoke-induced immune responses in the lung we performed bronchoscopy with bronchoalveolar lavage (BAL) on smokers and non-smokers, both MS-patients and healthy volunteers. In the BAL, non-smokers with MS showed an increased preformed CD40L expression in CD4(+) T-cells while smokers displayed an increase in...
Paper Details
Title
T-cell activation and HLA-regulated response to smoking in the deep airways of patients with multiple sclerosis
Published Date
Aug 1, 2016
Journal
Volume
169
Pages
114 - 120
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Notes
History