Inhibition of EZH2 Ameliorates Lupus‐Like Disease in MRL/lpr Mice

Objective We previously identified a role for EZH2, a transcriptional regulator in inducing proinflammatory epigenetic changes in lupus CD4+ T cells. This study was undertaken to investigate whether inhibiting EZH2 ameliorates lupus‐like disease in MRL/ lpr mice. Methods EZH2 expression levels in multiple cell types in lupus patients were evaluated using flow cytometry and messenger RNA expression data. Inhibition of EZH2 in MRL/ lpr mice was...