Programmed cell death

Cell biology

Haematopoiesis

Neuroscience

Biology

Remyelination

Apoptosis

Stem cell

Neuroinflammation

Regeneration (biology)

Biochemistry

Immunology

Microglia

Repopulation

Central nervous system

Inflammation

Myelin

Proinflammatory cytokine

Medicine

Necroptosis

Nature Neuroscience

Failed regeneration of CNS myelin contributes to clinical decline in neuroinflammatory and neurodegenerative diseases, for which there is an unmet therapeutic need. Here we reveal that efficient remyelination requires death of proinflammatory microglia followed by repopulation to a pro-regenerative state. We propose that impaired microglia death and/or repopulation may underpin dysregulated microglia activation in neurological diseases, and we reveal therapeutic targets to promote white matter regeneration.

Central nervous system regeneration is driven by microglia necroptosis and repopulation