Organic chemistry

Amination

Combinatorial chemistry

Biology

Catalysis

Halide

Chemistry

Ecology

Substrate (aquarium)

Alkyl

Coupling reaction

Aryl

Angewandte Chemie International Edition

The Pd‐catalyzed coupling of aryl (pseudo)halides and amines is one of the most powerful approaches for the formation of C(sp 2 )−N bonds. The pioneering reports from Migita and subsequently Buchwald and Hartwig on the coupling of aminostannanes and aryl bromides rapidly evolved into general and practical tin‐free protocols with broad substrate scope, which led to the establishment of what is now known as the Buchwald–Hartwig amination. This Minireview summarizes the evolution of this cross‐coupling reaction over the course of the past 25 years and illustrates some of the most recent applications of this well‐established methodology.

The Buchwald–Hartwig Amination After 25 Years