Original paper
A Systems Pharmacology Approach Uncovers Wogonoside as an Angiogenesis Inhibitor of Triple-Negative Breast Cancer by Targeting Hedgehog Signaling
Abstract
Highlights•A systems pharmacology approach uncovers wogonoside as a TNBC angiogenesis inhibitor•Network analysis identifies that wogonoside inhibits VEGF expression in TNBC•Wogonoside inhibits the Gli1 nuclear translocation and transcription activities•Wogonoside promotes Smoothened (SMO) degradation in a proteasome-dependent mechanismSummaryTriple-negative breast cancer (TNBC) is an aggressive and heterogeneous disease that lacks clinically...
Paper Details
Title
A Systems Pharmacology Approach Uncovers Wogonoside as an Angiogenesis Inhibitor of Triple-Negative Breast Cancer by Targeting Hedgehog Signaling
Published Date
Jun 6, 2019
Journal
Volume
26
Issue
8
Pages
1143 - 1158.e6