Poloxamer-based in situ gelling thermoresponsive systems for ocular drug delivery applications

In situ gels have recently received interest as ocular drug delivery vehicles because they combine the merits of easy instillation and sustained drug release. In this review, we focus on the use of poloxamers as in situ gelling systems in ocular drug delivery because of their thermoresponsive gelling behaviour, biocompatibility, and ease of sterilisation. Furthermore, the sol–gel transition temperature, mucoadhesive properties, and drug release...