Therapeutic Index Associated with Lymphadenectomy Among Patients with Intrahepatic Cholangiocarcinoma: Which Patients Benefit the Most from Nodal Evaluation?

Kota Sahara; Diamantis I. Tsilimigras; Katiuscha Merath; Fabio Bagante; Alfredo Guglielmi; Luca Aldrighetti; Matthew J. Weiss; Todd W. Bauer; Sorin Alexandrescu; George A. Poultsides; Timothy M. Pawlik

doi:https://doi.org/10.1245/s10434-019-07483-9

doi.org/10.1245/s10434-019-07483-9

Therapeutic Index Associated with Lymphadenectomy Among Patients with Intrahepatic Cholangiocarcinoma: Which Patients Benefit the Most from Nodal Evaluation?

Kota Sahara

24

,

Diamantis I. Tsilimigras

34

,

..., Timothy M. Pawlik

107

Annals of Surgical Oncology3.70

Volume: 26, Issue: 9, Pages: 2959 - 2968

Published: May 31, 2019

Abstract

Although lymph node metastasis (LNM) is an important prognostic indicator for patients with intrahepatic cholangiocarcinoma (ICC), the benefit and indication for lymphadenectomy remain unclear. Patients diagnosed with ICC between 1990 and 2016 were identified in the international multi-institutional dataset. To determine the survival benefit from lymphadenectomy, the therapeutic index was calculated by multiplying the frequency of LNM in a...