Application of Online Liquid Chromatography 7 T FT-ICR Mass Spectrometer Equipped with Quadrupolar Detection for Analysis of Natural Organic Matter.

Published on May 22, 2019in Analytical Chemistry6.785
· DOI :10.1021/ACS.ANALCHEM.9B00689
Donghwi Kim7
Estimated H-index: 7
(KNU: Kyungpook National University),
Sungjune Kim2
Estimated H-index: 2
(KNU: Kyungpook National University)
+ 2 AuthorsSunghwan Kim37
Estimated H-index: 37
(KNU: Kyungpook National University)
In this study, Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), combined with quadrupolar detection (QPD), was applied for online liquid chromatography (LC) MS analysis of natural organic matter (NOM). Although FT-ICR MS has emerged as an important analytical technique to study NOM, there are few previous reports on online LC FT-ICR MS analysis of NOM due to the long acquisition time (2–8 s) required to obtain high-resolution mass spectra. The QPD technique provides a critical advantage over the conventional dipolar detection (DPD) technique for LC-MS analysis because a spectrum with the same resolving power can be obtained in approximately half the acquisition time. QPD FT-ICR MS provides resolving powers (mΔm50%) of ∼300000 and 170000 at m/z 400 with acquisition times per scan of 1.2 and 0.8 s, respectively. The reduced acquisition time per scan allows increased number of acquisitions in a given LC analysis time, resulting in improved signal to noise (S/N) ratio and dynamic range...
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