Retinal pigment epithelium

Corneal epithelium

Retinal

Ophthalmology

Biochemistry

Cornea

Liposome

Bioavailability

Drug

Immunology

Drug delivery

Drug carrier

Organic chemistry

Oxidative stress

Inflammation

Macular degeneration

Pharmacology

Medicine

Chemistry

Journal of Nanobiotechnology

Age-related macular degeneration (AMD) is a leading cause of severe visual deficits and blindness. Meanwhile, there is convincing evidence implicating oxidative stress, inflammation, and neovascularization in the onset and progression of AMD. Several studies have identified berberine hydrochloride and chrysophanol as potential treatments for ocular diseases based on their antioxidative, antiangiogenic, and anti-inflammatory effects. Unfortunately, their poor stability and bioavailability have limited their application. In order to overcome these disadvantages, we prepared a compound liposome system that can entrap these drugs simultaneously using the third polyamidoamine dendrimer (PAMAM G3.0) as a carrier.PAMAM G3.0-coated compound liposomes exhibited appreciable cellular permeability in human corneal epithelial cells and enhanced bio-adhesion on rabbit corneal epithelium. Moreover, coated liposomes greatly improved BBH bioavailability. Further, coated liposomes exhibited obviously protective effects in human retinal pigment epithelial cells and rat retinas after photooxidative retinal injury. Finally, administration of P-CBLs showed no sign of side effects on ocular surface structure in rabbits model.The PAMAM G3.0-liposome system thus displayed a potential use for treating various ocular diseases.

Liposomes for effective drug delivery to the ocular posterior chamber