Original paper
Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen
Abstract
The manipulation of dendritic cells (DCs) for cancer vaccination has not reached its full potential, despite the revolution in cancer immunotherapy. DCs are fundamental for CD8+ T cell activation, which relies on cross-presentation of exogenous antigen on MHC-I and can be fostered by immunogenic cancer cell death. Translational and clinical research has focused on in vitro-generated monocyte-derived DCs, while the vaccination efficacy of natural...
Paper Details
Title
Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen
Published Date
Apr 8, 2019
Volume
7
Issue
1
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