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Review paper

Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer

Volume: 98, Pages: 34 - 43
Published: May 22, 2019
Abstract
Metabolic reprogramming in cancer targets glutamine metabolism as a key mechanism to provide energy, biosynthetic precursors and redox requirements to allow the massive proliferation of tumor cells. Glutamine is also a signaling molecule involved in essential pathways regulated by oncogenes and tumor suppressor factors. Glutaminase isoenzymes are critical proteins to control glutaminolysis, a key metabolic pathway for cell proliferation and...
Paper Details
Title
Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer
Published Date
May 22, 2019
Volume
98
Pages
34 - 43
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