Review paper
Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer
Abstract
Metabolic reprogramming in cancer targets glutamine metabolism as a key mechanism to provide energy, biosynthetic precursors and redox requirements to allow the massive proliferation of tumor cells. Glutamine is also a signaling molecule involved in essential pathways regulated by oncogenes and tumor suppressor factors. Glutaminase isoenzymes are critical proteins to control glutaminolysis, a key metabolic pathway for cell proliferation and...
Paper Details
Title
Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer
Published Date
May 22, 2019
Volume
98
Pages
34 - 43