Abstract Four new alkaloid glycosides, zanthonitisides A–D (1-4), together with five known compounds (5–9) were isolated from the aqueous fraction of stems and twigs of Zanthoxylum nitidum (Roxb.) DC. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, MS, and CD data. All isolated compounds were evaluated for their cytotoxic activity against three human cancer cell lines, CT-26, MCF-7, and MKN-45. As results, compound 4 showed significant cytotoxic activity on MKN-45 cancer cell line with IC50 value of 7.4 ± 1.0 μM. Compound 9 exhibited moderate cytotoxic activity on all tested cancer cell lines with an IC50 values ranging from 34.7 to 44.7 μM.
Abstract Background Methicillin-resistant Staphylococcus aureus (MRSA) poses a serious therapeutic challenge in current clinic and new drug development. Natural coumarins have diverse bioactivities and the potential of resistance modifying effects. Purpose This study is to present in-depth evaluations of in vitro antimicrobial activities of four natural coumarins 5-geranyloxy-7-methoxycoumarin (Gm, 1), (5,7-dimethoxy-8-prenyloxycoumarin (artanin, Ar, 2)), isopimpinellin (Is, 3) and phellopterin ...
Two novel prenylated benzophenone related meroterpenes, hypatulins A (1) and B (2), were isolated from the leaves of Hypericum patulum. The structures of 1 and 2 were assigned by spectroscopic analysis, chemical conversion, and calculations of the ECD (electron circular dichroism) spectra. Hypatulin A (1) had a unique densely substituted tricyclic octahydro-1,5-methanopentalene core, while hypatulin B (2) possessed a bicyclo[3.2.1]octane moiety. Hypatulin A (1) exhibited antimicrobacterial activ...
Abstract Eight oleanane- type saponins, glomerulosides A–H, were isolated from leaves of Glochidion glomerulatum. All isolated compounds were evaluated for cytotoxic activity on four human cancer cell lines, A-549, HT-29, OVCAR, and MCF-7. Glomerulosides C and E, which contain a benzoyloxy group at C-22, showed significant cytotoxic activities against the A-549, HT-29, and OVCAR cancer cell lines with IC 50 values ranging from 5.9 to 9.8 μM. Glomeruloside A showed cytotoxicity on HT-29 and OVCAR...
#1Cheng-Fang Wang(CCDC: Chinese Center for Disease Control and Prevention)H-Index: 16
#2Li Fan(CCDC: Chinese Center for Disease Control and Prevention)H-Index: 6
Last. Xu Su(CCDC: Chinese Center for Disease Control and Prevention)H-Index: 4
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This work aimed to investigate benzophenanthridine from the roots of Zanthoxylum nitidum (Roxb.) DC. var. fastuosum How ex Huang for the first time. Thirteen benzophenanthridines were isolated, and our results of the cytotoxic activities indicated that compound 6 exhibited the best potency against A549, Hela, SMMC-7721 and EJ, with the IC50 values of 27.50, 37.50, 16.95 and 60.42 μM, respectively. Compounds 7 and 11 also showed strong cytotoxicity when tested against the four human cancer cell l...
#1Ziqiang Wang(ECNU: East China Normal University)H-Index: 4
#2Wei Jiang(ECNU: East China Normal University)H-Index: 2
Last. Bing Du(ECNU: East China Normal University)H-Index: 22
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Abstract Ethnopharmacological relevance Zanthoxylum nitidium (Roxb.) DC. has long been used as a traditional herbal medicine for inflammatory diseases such as rheumatic arthritis and peridentitis. However, the anti-inflammatory mechanism of Nitidine chloride has not been fully elucidated. Aim of the study To determine the anti-inflammatory effects and mechanism of Nitidine chloride (NTD), a pentacyclic alkaloid is isolated from the root of Z. nitidium , in murine macrophages. Materials and metho...
Last. Ih-Sheng Chen(KMU: Kaohsiung Medical University)H-Index: 42
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Abstract Zanthoxylum nitidum is commercially used in healthcare products for the improvement of tooth condition. Its fruit is also used as a spice. Three new benzenoids, ( E )-4-(4-hydroxy-3-methylbut-2-enyloxy)benzaldehyde ( 1 ), ( E )-methyl 3-(4-(( E )-4-hydroxy-3-methylbut-2-enyloxy)phenyl)acrylate ( 2 ), and ( Z )-methyl 3-(4-(( E )-4-hydroxy-3-methylbut-2-enyloxy)phenyl)acrylate ( 3 ), have been isolated from the stem wood of Z. nitidum , together with 17 known compounds ( 4 – 20 ). The st...
Five alkaloids, 5,6-dihydro-6-methoxynitidine (1), dictamnine (2), γ-fagarine (3), skimmianine (4), and 5-methoxydictamnine (5), were isolated from the roots of Zanthoxylum nitidum. Their structures and configurations were elucidated by spectroscopic methods and X-ray analysis. Compounds 1, 4, and 5 showed in vitro antiviral effect against hepatitis B virus, and compounds 2, 3, and 5 demonstrated marked antimitotic and antifungal activity.
#1Cheng-Hui Yang(KMU: Kaohsiung Medical University)H-Index: 2
#2Ming‐Jen Cheng(NSYSU: National Sun Yat-sen University)H-Index: 10
Last. Ih-Sheng Chen(NSYSU: National Sun Yat-sen University)H-Index: 2
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Five novel alkaloids, zanthomuurolanine (1), epi-zanthomuurolanine (2), zanthocadinanines A (3) and B (4), and epi-zanthocadinanine B (5), composed of dihydrochelerythrine and a cadinane-type sesquiterpene linked by a methylene bridge, have been isolated from stem bark of Zanthoxylum nitidum. These structures were elucidated by spectroscopic techniques (UV, IR, MS, CD, 1H NMR, 13C NMR, DEPT, COSY, NOESY, HSQC, and HMBC analyses). Single-crystal X-ray diffraction studies confirmed the relative co...
#1Xin-Gang Cui('SMMU': Second Military Medical University)H-Index: 1
#2Qingjie Zhao('SMMU': Second Military Medical University)H-Index: 13
Last. Dan-Feng Xu('SMMU': Second Military Medical University)H-Index: 1
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Two new benzophenanthridine alkaloids, named 8-methoxysanguinarine (1) and 8-methoxyisodecarine (2), were isolated from the EtOH extract of the rhizoma of Zanthoxylum nitidum. Their structures were determined on the basis of spectroscopic analysis.
#1Feng Qin(GXNU: Guangxi Normal University)H-Index: 1
#2Cai Yi Wang(SNU: Seoul National University)H-Index: 2
Last. Dong Liang(GXNU: Guangxi Normal University)H-Index: 9
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Nitidumpeptins A and B (1 and 2), two novel cyclic hexapeptides, were isolated from the herb Zanthoxylum nitidum var. tomentosum. Their planar structures were elucidated based on NMR and MS spectrometric analysis, and the absolute configurations were determined by the Marfey's method. Structurally, 1 is a unique peptide with a backbone bearing a pyrrolidine-2,5-dione unit, which is the first occurrence moiety specifically in a naturally occurring cyclohexapeptide. The total synthesis of 1 and 2 ...
#2Adriana Nowak(TUL: Lodz University of Technology)H-Index: 17
Last. Agnieszka Nowak(TUL: Lodz University of Technology)H-Index: 15
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Aronia melanocarpa, Cornus mas, and Chaenomeles superba leaf extracts contain large amounts of bioactive compounds—mainly polyphenols, which possess many health benefits including anti-cancer properties. Here, we investigate the biological effects of A. melanocarpa, C. mas, and C. superba leaf extracts on the human colon adenocarcinoma cell line Caco-2. The antiproliferative activity of the extracts was measured using the MTT assay. The most cytotoxic extract was C. mas (IC50 = 0.60%). The extra...
Abstract Ethnopharmacological relevance Zanthoxylum nitidum (Roxb.) DC. (Z. nitidum), which is known in China as Liang–Mian–Zhen, is mainly distributed in southern China and is widely used in traditional Chinese medicine. It is traditionally used for treating stomach ache, toothache, rheumatic arthralgia, traumatic injury and venomous snake bites. Additional medical applications include the treatment of inflammations, various types of cancer, bacterial and viral infections, gastric and oral ulce...
Last. Changhong Wang(SHU: Shanghai University)H-Index: 66
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Abstract Zanthoxylum nitidum (Roxb.) DC. (ZN) belongs to the genus Zanthoxylum of Rutaceae and has various chemical ingredients and pharmacologic effects. Alkaloids are its main active constituents responsible for diverse pharmacologic effects, such as anti-tumor, anti-bacterial, anti-inflammatory, and analgesic activities. The chemical and pharmacological effects of ZN are well reported, but the in vivo pharmacokinetic profiles of its main active alkaloids are poorly investigated. This study ai...
Abstract Sichuan pepper, commonly used as a food seasoning, possesses unique anti-diabetic properties. This study uses ultra-high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UHPLC-Q-TOF) to elucidate the chemical profile of Sichuan pepper. Further, an ultra-filtration was coupled with UHPLC-Q-TOF to screen the α-glucosidase inhibitors (AGIs) for the first time. Results confirmed significant variation in the content of hydroxyl-α-sanshool (HA...
