Alkaloid

Biology

Cell culture

Biochemistry

Stereochemistry

Cytotoxicity

Genetics

In vitro

Cytotoxic T cell

Cancer cell lines

Glycoside

IC50

Medicine

Chemistry

Zanthoxylum

Cancer

Traditional medicine

Cancer cell

Phytochemistry Letters

Four new alkaloid glycosides, zanthonitisides A–D (1-4), together with five known compounds (5–9) were isolated from the aqueous fraction of stems and twigs of Zanthoxylum nitidum (Roxb.) DC. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, MS, and CD data. All isolated compounds were evaluated for their cytotoxic activity against three human cancer cell lines, CT-26, MCF-7, and MKN-45. As results, compound 4 showed significant cytotoxic activity on MKN-45 cancer cell line with IC50 value of 7.4 ± 1.0 μM. Compound 9 exhibited moderate cytotoxic activity on all tested cancer cell lines with an IC50 values ranging from 34.7 to 44.7 μM.

Alkaloid glycosides and their cytotoxic constituents from Zanthoxylum nitidum