Alkaloid glycosides and their cytotoxic constituents from Zanthoxylum nitidum

Published on Aug 1, 2019in Phytochemistry Letters1.459
· DOI :10.1016/J.PHYTOL.2019.04.022
Nguyen Thi Hong Van1
Estimated H-index: 1
(VAST: Vietnam Academy of Science and Technology),
Tran Thi Tuyen2
Estimated H-index: 2
(VAST: Vietnam Academy of Science and Technology)
+ 9 AuthorsSeung Hyun Kim6
Estimated H-index: 6
(Yonsei University)
Sources
Abstract
Abstract Four new alkaloid glycosides, zanthonitisides A–D (1-4), together with five known compounds (5–9) were isolated from the aqueous fraction of stems and twigs of Zanthoxylum nitidum (Roxb.) DC. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, MS, and CD data. All isolated compounds were evaluated for their cytotoxic activity against three human cancer cell lines, CT-26, MCF-7, and MKN-45. As results, compound 4 showed significant cytotoxic activity on MKN-45 cancer cell line with IC50 value of 7.4 ± 1.0 μM. Compound 9 exhibited moderate cytotoxic activity on all tested cancer cell lines with an IC50 values ranging from 34.7 to 44.7 μM.
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