The role of estrogen receptor subtypes in ovarian hormonal therapy

3272 null Estrogen, a steroid hormone mainly synthesized in the ovary, regulates the expression of genes that are responsible for cell proliferation, apoptosis, tumor metastasis and invasion. The effects of estrogen are mediated through estrogen receptors (ER). Previous investigations demonstrated that two major subtypes of ER (α and β) had opposing effects on cell proliferation: ERα promoted cell proliferation, whereas ERβ induced cell...