Abstract 18987: Domain Specific Interaction of Kir2.2 and Cav3: Implications for Atrial Fibrillation

Introduction: In human ventricle Kir2.1 comprises the major component of IK1, but the Kir2.2 isoform dominates in the atria. Thus Kir2.2 regulation may have specific impact in atrial arrhythmias such as atrial fibrillation. Caveolin-3 (Cav3) forms caveolar rafts and plays a key role in assembling macromolecular signaling complexes for cardiac ion channels. Cav3 is implicated in ion channel misplacement in heart failure leading to atrial...