IL-23 and dendritic cells: What are the roles of their mutual attachment in immune response and immunotherapy?
Abstract
Interleukin-23 (IL-23) is a cytokine that is composed of the subunits p19 and p40, while its receptor (IL-23R) consists of two subunits, that is, IL-23Rα and IL-12Rβ1. The interaction between IL-23 and IL-23R is necessary for exerting cardinal biological effects upon certain cell types, including promotion of memory T cell proliferation and Th17 cell-mediated IL-17 secretion. Accordingly, dendritic cells (DCs) are one of the main sources for...
Paper Details
Title
IL-23 and dendritic cells: What are the roles of their mutual attachment in immune response and immunotherapy?
Published Date
Aug 1, 2019
Journal
Volume
120
Pages
78 - 84
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Notes
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