Global Myocardial Work Is Superior to Global Longitudinal Strain to Predict Significant Coronary Artery Disease in Patients With Normal Left Ventricular Function and Wall Motion

•Calculation of myocardial work incorporates both strain and afterload. •Myocardial work can now be derived from noninvasive pressure-strain loops. •Myocardial work is superior to GLS in predicting CAD. •Myocardial work can assess early subclinical ischemic myocardial dysfunction. Background Noninvasive detection of functionally significant coronary artery disease (CAD) by echocardiography remains challenging, with the need to perform stress...