Radical-nucleophilic aromatic substitution

Organic chemistry

Ring (chemistry)

Stereochemistry

Nucleophilic aromatic substitution

Substitution reaction

Electrophilic aromatic substitution

Catalysis

Nucleophilic substitution

Nucleophile

Computational chemistry

Medicinal chemistry

Aromaticity

Chemistry

Molecule

Concerted reaction

Angewandte Chemie International Edition

Recent developments in experimental and computational chemistry have identified a rapidly growing class of nucleophilic aromatic substitutions that proceed by concerted (cS N Ar) rather than classical, two‐step, S N Ar mechanisms. Whereas traditional S N Ar reactions require substantial activation of the aromatic ring by electron‐withdrawing substituents, such activating groups are not mandatory in the concerted pathways.

Concerted Nucleophilic Aromatic Substitution Reactions