Structural characterization and antitumor effects of chitosan oligosaccharides against orthotopic liver tumor via NF-κB signaling pathway

Increasing studies have reported the antitumor effects of chitosan oligosaccharides (COS) against multiple cancer, including S180, colon tumor, etc. Here, the structural characters of COS were identified and its inhibitory effects against orthotopic liver tumor and immunoregulation effects were also studied. Degree of polymerization (DP) of COS is 2–6, degree of deacetylation (DD) is 98.38 ± 1.34%. COS is positive charged with zeta potential at...