Pathways Exploited by Flaviviruses to Counteract the Blood-Brain Barrier and Invade the Central Nervous System

Human infection by different Flaviviruses may cause severe neurologic syndromes, through pathogenic mechanisms that are still largely unknown. Japanese Encephalitis virus (JEV), West Nile virus (WNV), Zika virus (ZIKV), Yellow Fever virus (YFV), Dengue virus (DENV), and Tick-borne Encephalitis virus (TBEV) are believed to reach the central nervous system by a hematogenous route, upon crossing the blood brain barrier. Although the disruption of...