Inherent and unpredictable bias in multi-component DESPOT myelin water fraction estimation
Abstract
Multicomponent driven equilibrium steady-state observation of T1 and T2 (mcDESPOT) aims to quantify the Myelin Water Fraction (MWF) using a two-pool microstructural model. The MWF has been used to track neurodevelopment and neurodegeneration and has been histologically correlated to myelin content. mcDESPOT has a clinically feasible acquisition time and high signal-to-noise ratio (SNR) relative to other MWF techniques. However, disagreement...
Paper Details
Title
Inherent and unpredictable bias in multi-component DESPOT myelin water fraction estimation
Published Date
Jul 1, 2019
Journal
Volume
195
Pages
78 - 88
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