Cyclosporine and prednisolone combination therapy as a potential therapeutic strategy for relentless placoid chorioretinitis.

Published on Mar 23, 2019in American Journal of Ophthalmology Case Reports
· DOI :10.1016/J.AJOC.2019.03.005
Takehiko Uraki2
Estimated H-index: 2
(Hokkaido University),
Kenichi Namba28
Estimated H-index: 28
(Hokkaido University)
+ 4 AuthorsSusumu Ishida52
Estimated H-index: 52
(Hokkaido University)
Abstract Purpose Relentless placoid chorioretinitis (RPC) is a new disease concept that was proposed by Jones et al. in 2000. Some cases of RPC have been reported; however, a treatment strategy has not yet been established. We report herein four cases of patients diagnosed with RPC. Observations We experienced four cases of RPC in patients aged 24–51 years. All patients exhibited retinal lesions similar to that seen in acute posterior multifocal placoid pigment epitheliopathy or serpiginous choroiditis from the posterior pole to the surrounding region. Although patients underwent systemic prednisolone (PSL) therapy, recurrence was observed and the retinal scar formation was progressive; they were then diagnosed with RPC. In all cases, cyclosporine (CyA) was administered in addition to PSL, no recurrence was observed thereafter. Conclusions and Importance RPC is a rare disease, and a treatment strategy has not yet been established. CyA and PSL combination therapy is considered to be effective in the treatment of RPC.
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