Periaqueductal Gray Sheds Light on Dark Areas of Psychopathology

New animal/rodent data that utilize modern functional track tracing with optogenetics and designer receptors exclusively activated by designer drugs (DREADDS) technology show that the periaqueductal gray (PAG) is a rich substrate for the integration of active and passive responses to threat. Human data suggest that the PAG may be dysregulated in psychopathology that drives maladaptive behavior. The neural circuit that connects the frontal...