Network meta‐analysis of rare events using the Mantel‐Haenszel method

The Mantel‐Haenszel (MH) method has been used for decades to synthesize data obtained from studies that compare two interventions with respect to a binary outcome. It has been shown to perform better than the inverse‐variance method or Peto's odds ratio when data is sparse. Network meta‐analysis (NMA) is increasingly used to compare the safety of medical interventions, synthesizing, eg, data on mortality or serious adverse events. In this...