Internal medicine

Receptor

Eplerenone

Pathophysiology

Endocrinology

Mineralocorticoid

Mineralocorticoid receptor

Kidney

Kidney disease

Medicine

Kidney International

Chronic kidney disease (CKD) represents a global health concern, and its prevalence is increasing. The ultimate therapeutic option for CKD is kidney transplantation. However, the use of drugs that target specific pathways to delay or halt CKD progression, such as angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and sodium-glucose co-transporter-2 (SGLT-2) inhibitors is limited in clinical practice. Mineralocorticoid receptor activation in nonclassical tissues, such as the endothelium, smooth muscle cells, inflammatory cells, podocytes, and fibroblasts may have deleterious effects on kidney structure and function.

Mineralocorticoid receptor antagonists and kidney diseases: pathophysiological basis