Integrating of genomic and transcriptomic profiles for the prognostic assessment of breast cancer

Published on Mar 13, 2019in Breast Cancer Research and Treatment3.831
· DOI :10.1007/S10549-019-05177-0
C. Wang5
Estimated H-index: 5
Sources
Abstract
Purpose To evaluate the prognostic effect of the integration of genomic and transcriptomic profiles in breast cancer.
📖 Papers frequently viewed together
6 Authors (Jian-Guo Zhou, ..., Hu Ma)
8 Citations
88 Citations
References42
Newest
#1Jianguo Lai (SYSU: Sun Yat-sen University)H-Index: 4
#2Hongli Wang (SYSU: Sun Yat-sen University)H-Index: 5
Last. Zihao Pan (SYSU: Sun Yat-sen University)H-Index: 4
view all 5 authors...
Background: The eighth edition of the American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) staging system for survival prediction and risk stratification in breast cancer (BC) patients after neoadjuvant chemotherapy (NCT) is of limited efficacy. This study aimed to establish a novel prognostic nomogram for predicting disease-free survival (DFS) in BC patients after NCT. Patients and methods: A total of 567 BC patients treated with NCT, from two independent centers, were included...
10 CitationsSource
#1Bo Lan (Peking Union Medical College)H-Index: 8
#2Fei Ma (Peking Union Medical College)H-Index: 18
Last. Binghe Xu (Peking Union Medical College)H-Index: 31
view all 13 authors...
: Variants of the CYP2D6 gene may lead to a poor prognosis of tamoxifen (TAM)-treated patients. Our study validated the association between the CYP2D6 genotype and outcomes of patients receiving TAM in adjuvant endocrine therapy. A total of 778 breast cancer patients who received adjuvant TAM (n = 325) or aromatase inhibitors (AIs) (n = 453) at the National Cancer Center were analyzed. Nine single nucleotide polymorphisms (SNPs) in the CYP2D6 gene were selected from online databases. The associa...
18 CitationsSource
#1Bingchen Han (Cedars-Sinai Medical Center)H-Index: 14
#2Bo Zhou (Cedars-Sinai Medical Center)H-Index: 8
Last. Xiaojiang Cui (Cedars-Sinai Medical Center)H-Index: 30
view all 10 authors...
Triple-negative breast cancer (TNBC) has high rates of local recurrence and distant metastasis, partially due to its high invasiveness. The Forkhead box C1 (FOXC1) transcription factor has been shown to be specifically overexpressed in TNBC and associated with poor clinical outcome. How TNBC’s high invasiveness is driven by FOXC1 and its downstream targets remains poorly understood. In the present study, pathway-specific PCR array assays revealed that WNT5A and matrix metalloproteinase-7 (MMP7) ...
39 CitationsSource
#1M. Rudolph (OSU: Ohio State University)H-Index: 1
#2Steven T. Sizemore (OSU: Ohio State University)H-Index: 10
Last. Bhuvaneswari Ramaswamy (OSU: Ohio State University)H-Index: 24
view all 11 authors...
Purpose High expression of glioma-associated oncogene homolog-1 (GLI1) is associated with poor prognosis in estrogen receptor (ER) positive breast cancers. We sought to define a GLI1-dependent gene signature in ER-positive tumors that could further stratify patients at higher risk for disease recurrence and potentially lead to novel combination therapies.
7 CitationsSource
#1Nam Nhut Phan (CCU: Chinese Culture University)H-Index: 9
#2Chih Yang Wang (NCKU: National Cheng Kung University)H-Index: 16
Last. Yen Chang Lin (CCU: Chinese Culture University)H-Index: 7
view all 8 authors...
// Nam Nhut Phan 1, 2, * , Chih-Yang Wang 3, * , Kuan-Lun Li 1 , Chien-Fu Chen 4 , Chung-Chieh Chiao 4 , Han-Gang Yu 5 , Pung-Ling Huang 1, 6 and Yen-Chang Lin 1 1 Graduate Institute of Biotechnology, Chinese Culture University, Taipei, Taiwan 2 NTT Institute of Hi-Technology, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam 3 Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan 4 School o...
39 CitationsSource
#1Caroline O. Terranova (UQ: University of Queensland)H-Index: 6
#2Melinda M. Protani (UQ: University of Queensland)H-Index: 15
Last. Marina M. Reeves (UQ: University of Queensland)H-Index: 36
view all 3 authors...
ABSTRACTBreast cancer survivors often seek information about how lifestyle factors, such as diet, may influence their prognosis. Previous studies have reviewed evidence around single nutrients, individual foods or food groups. We reviewed studies examining relationships between overall dietary intake and prognosis in breast cancer survivors. A systematic search was conducted to identify studies, published until June 2016, which assessed associations between overall dietary intake (i.e., quality;...
10 CitationsSource
#1Lee D. Gibbs (University of North Texas Health Science Center)H-Index: 6
#2Jamboor K. Vishwanatha (University of North Texas Health Science Center)H-Index: 43
// Lee D. Gibbs 1 and Jamboor K. Vishwanatha 1 1 Institute for Molecular Medicine and Texas Center for Health Disparities, University of North Texas Health Science Center, Fort Worth, TX 76017, USA Correspondence to: Lee D. Gibbs, email: Lee.Gibbs@live.unthsc.edu Keywords: annexin; triple-negative breast cancer; prognosis; survival; relapse Received: June 12, 2017 Accepted: December 08, 2017 Published: December 23, 2017 ABSTRACT Objective: Previous studies have shown Annexin A1 (AnxA1) and Annex...
15 CitationsSource
#1Satbir Thakur (U of C: University of Calgary)H-Index: 10
#2Haocheng Li (U of C: University of Calgary)H-Index: 9
Last. Hua Yang (U of C: University of Calgary)H-Index: 2
view all 8 authors...
Ki67 is a commonly used marker of cancer cell proliferation, and has significant prognostic value in breast cancer. In spite of its clinical importance, assessment of Ki67 remains a challenge, as current manual scoring methods have high inter- and intra-user variability. A major reason for this variability is selection bias, in that different observers will score different regions of the same tumor. Here, we developed an automated Ki67 scoring method that eliminates selection bias, by using whol...
23 CitationsSource
#1Biao Wang (SDU: Shandong University)H-Index: 1
#2Zhen Tang (Bengbu Medical College)H-Index: 3
Last. Xue-gang Liu (Bengbu Medical College)H-Index: 3
view all 5 authors...
A recent study indicated that high Wnt5a expression is associated with poor prognosis in non-small-cell lung cancer (NSCLC) patients; however, the underlying mechanism was not clear yet. Immunohistochemistry and Western blotting were performed to examine the protein expression level in NSCLC tissues and cell lines. The role of Wnt5a in clone formation, invasiveness, migration, and epithelial-to-mesenchymal transition (EMT) of NSCLC cells was studied. Luciferase reporter assay was used to evaluat...
25 CitationsSource
#1Chao-Qun Wang (WMU: Wenzhou Medical College)H-Index: 6
#2Chih-Hsin Tang (PRC: China Medical University (PRC))H-Index: 72
Last. Chen-Ming Su (WMU: Wenzhou Medical College)H-Index: 16
view all 10 authors...
Breast cancer is a major cause of cancer mortality worldwide. Fascin-1 (FSCN1) is an actin-binding protein found in mammalian cells, including endothelial, neuronal and mesenchymal cells. FSCN1 overexpression has been indicated in breast cancer patients. However, scant information is available regarding the association between FSCN1 single nucleotide polymorphisms (SNPs) and the risk or prognosis of breast cancer. We report on the association between 6 SNPs of the FSCN1 gene (rs56156320, rs8772,...
22 CitationsSource
Cited By2
Newest
#1X. L. Yang (SDU: Shandong University)H-Index: 10
#2Juan Li (SDU: Shandong University)H-Index: 21
Last. Chuanxin Wang (SDU: Shandong University)H-Index: 28
view all 12 authors...
Deregulations of long non-coding RNAs (lncRNAs) have been implicated in the progression of breast cancer (BC). However, the prognostic values of those lncRNAs in BC remain elusive. This study aimed at constructing a lncRNA-based prognostic model to improve the clinical management of BC. Systematic investigation of lncRNA expression profiles and clinical data from The Cancer Genome Atlas (TCGA) database were utilized to establish a 10-lncRNA signature. The prognostic signature efficiently discrim...
Source
#1Jianguo Lai (Academy of Medical Sciences, United Kingdom)H-Index: 3
#2Bo Chen (Peking Union Medical College)H-Index: 11
Last. Ning Liao (Peking Union Medical College)H-Index: 6
view all 6 authors...
Accumulating evidence revealed that autophagy played vital roles in breast cancer (BC) progression. Thus, the aim of this study was to investigate the prognostic value of autophagy-related genes (ARGs) and develop a ARG-based model to evaluate 5-year overall survival (OS) in BC patients. We acquired ARG expression profiling in a large BC cohort (N = 1007) from The Cancer Genome Atlas (TCGA) database. The correlation between ARGs and OS was confirmed by the LASSO and Cox regression analyses. A pr...
8 CitationsSource