Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements

Volume: 51, Issue: 4, Pages: 705 - 715
Published: Mar 4, 2019
Abstract
Cancer genomes are frequently characterized by numerical and structural chromosomal abnormalities. Here we integrated a centromere-specific inactivation approach with selection for a conditionally essential gene, a strategy termed CEN-SELECT, to systematically interrogate the structural landscape of mis-segregated chromosomes. We show that single-chromosome mis-segregation into a micronucleus can directly trigger a broad spectrum of genomic...
Paper Details
Title
Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements
Published Date
Mar 4, 2019
Volume
51
Issue
4
Pages
705 - 715
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