Original paper
Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements
Abstract
Cancer genomes are frequently characterized by numerical and structural chromosomal abnormalities. Here we integrated a centromere-specific inactivation approach with selection for a conditionally essential gene, a strategy termed CEN-SELECT, to systematically interrogate the structural landscape of mis-segregated chromosomes. We show that single-chromosome mis-segregation into a micronucleus can directly trigger a broad spectrum of genomic...
Paper Details
Title
Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements
Published Date
Mar 4, 2019
Journal
Volume
51
Issue
4
Pages
705 - 715
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Notes
History