Review paper
Strategies for the discovery of biased GPCR ligands
Abstract
G-protein-coupled receptors (GPCRs) represent important drug targets with complex pharmacological characteristics. Biased signaling represents one important dimension, describing ligand-dependent shifts of naturally imprinted signaling profiles. Because biased GPCR modulators provide potential therapeutic benefits including higher efficiencies and reduced adverse effects, the identification of such ligands as drug candidates is highly desirable....
Paper Details
Title
Strategies for the discovery of biased GPCR ligands
Published Date
Apr 1, 2019
Journal
Volume
24
Issue
4
Pages
1031 - 1037
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