Original paper
Identification of a peptide antagonist of the FGF 1–FGFR 1 signaling axis by phage display selection
Abstract
Overexpression of fibroblast growth factor receptor 1 ( FGFR 1) is a common aberration in lung and breast cancers and has necessitated the design of drugs targeting FGFR 1‐dependent downstream signaling and FGFR 1 ligand binding. To date, the major group of drugs being developed for treatment of FGFR 1‐dependent cancers are small‐molecule tyrosine kinase inhibitors; however, the limited specificity of these drugs has led to increasing attempts...
Paper Details
Title
Identification of a peptide antagonist of the FGF 1–FGFR 1 signaling axis by phage display selection
Published Date
Apr 9, 2019
Journal
Volume
9
Issue
5
Pages
914 - 924
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Notes
History