Catalysis

Photosensitizer

Reactivity (psychology)

Ketone

Photochemistry

Nuclear physics

Alkyl

Alternative medicine

Physics

Organic chemistry

Photoredox catalysis

Hydrogen atom

Catalytic cycle

Radical

Excited state

Medicine

Chemistry

Nickel

Photocatalysis

Benzophenone

Pathology

Angewandte Chemie International Edition

A dual catalytic protocol for the direct arylation of non-activated C(sp3 )-H bonds has been developed. Upon photochemical excitation, the excited triplet state of a diaryl ketone photosensitizer abstracts a hydrogen atom from an aliphatic C-H bond. This inherent reactivity was exploited for the generation of benzylic radicals which subsequently enter a nickel catalytic cycle, accomplishing the benzylic arylation.

The Dual Role of Benzophenone in Visible‐Light/Nickel Photoredox‐Catalyzed C−H Arylations: Hydrogen‐Atom Transfer and Energy Transfer