Internal medicine

Composition (language)

Physiology

Colorectal cancer

Bioinformatics

Biology

Cancer

Clinical nutrition

Philosophy

Lipidology

Linguistics

Metabolism

Computational biology

Clinical chemistry

Medicine

Lipids in Health and Disease

Altered metabolism of lipids is currently considered a hallmark characteristic of many malignancies, including colorectal cancer (CRC). Lipids are a large group of metabolites that differ in terms of their fatty acid composition. This review summarizes recent evidence, documenting many alterations in the content and composition of fatty acids, polar lipids, oxylipins and triacylglycerols in CRC patients' sera, tumor tissues and adipose tissue. Some of altered lipid molecules may be potential biomarkers of CRC risk, development and progression. Owing to a significant role of many lipids in cancer cell metabolism, some of lipid metabolism pathways may also constitute specific targets for anti-CRC therapy.

Changes in lipids composition and metabolism in colorectal cancer: a review