Lipids in Health and Disease
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#1Xin-Ran Gao (Anhui Medical University)H-Index: 4
#2Zheng Chen (Anhui Medical University)H-Index: 2
Last. Jin-Fang Ge (Anhui Medical University)H-Index: 18
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Background null Quercetin (QUE) is a flavonol reported with anti-inflammatory and antioxidant activities, and previous results from the group of this study have demonstrated its neuroprotective effect against lipopolysaccharide-induced neuropsychiatric injuries. However, little is known about its potential effect on neuropsychiatric injuries induced or accompanied by metabolic dysfunction of glucose and lipids. null Methods null A nonalcoholic fatty liver disease (NAFLD) rat model was induced vi...
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#1Chunyuan Jiang (NCU: Nanchang University)
#2Ruijuan Yang (NCU: Nanchang University)
Last. Yang Zou (NCU: Nanchang University)H-Index: 3
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BACKGROUND Triglyceride glucose-body mass index (TyG-BMI) has been recommended as an alternative indicator of insulin resistance. However, the association between TyG-BMI and pre-diabetes remains to be elucidated. METHODS More than 100,000 subjects with normal glucose at baseline received follow-up. The main outcome event of concern was pre-diabetes defined according to the diagnostic criteria recommended by the American Diabetes Association (ADA) in 2018 and the World Health Organization (WHO) ...
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#1Do-Won Jeong (NGUC: New Generation University College)
#2Seulbee Lee (NGUC: New Generation University College)
Last. Yang-Sook Chun (NGUC: New Generation University College)H-Index: 24
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Reprogramming of lipid metabolism has received increasing recognition as a hallmark of cancer cells because lipid dysregulation and the alteration of related enzyme profiles are closely correlated with oncogenic signals and malignant phenotypes, such as metastasis and therapeutic resistance. In this review, we describe recent findings that support the importance of lipids, as well as the transcription factors involved in cancer lipid metabolism. With recent advances in transcription factor analy...
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#1Haibin LiH-Index: 11
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Last. Shunmin Li (GZUCM: Guangzhou University of Chinese Medicine)H-Index: 10
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#1Wen Li (SZU: Shenzhen University)
#2Xiaobin Wang (SZU: Shenzhen University)
Last. Zhifeng Wang (Zhengzhou University)
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Background null The high drug resistance and metabolic reprogramming of clear cell renal cell carcinoma (ccRCC) are considered responsible for poor prognosis. In-depth research at multiple levels is urgently warranted to illustrate the lipid composition, distribution, and metabolic pathways of clinical ccRCC specimens. null Methods null In this project, a leading-edge targeted quantitative lipidomic study was conducted using 10 pairs of cancerous and adjacent normal tissues obtained from ccRCC p...
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#1Xiaofeng Liu (FJMU: Fujian Medical University)H-Index: 1
#2Qingwen Lin (FJMU: Fujian Medical University)
Last. Qishui Ou (FJMU: Fujian Medical University)H-Index: 13
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BACKGROUND Increased evidence has reported the association of genetic polymorphisms of Apolipoprotein E (APOE) with serum lipids. However, few studies have explored the combined effects of APOE, gender, and age. METHODS A total of 1,419 middle-aged and elderly subjects were randomly selected and studied. The APOE genotypes and the serum lipids were detected. The effects of APOE, gender, and age on serum lipids were preliminarily observed in general. The subjects were then divided into the middle...
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#1Markus Blaess (HFU: Furtwangen University)H-Index: 8
#2Lars Kaiser (HFU: Furtwangen University)H-Index: 5
Last. Hans-Peter Deigner (HFU: Furtwangen University)H-Index: 27
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Rash, photosensitivity, erythema multiforme, and the acute generalized exanthematous pustulosis (AGEP) are relatively uncommon adverse reactions of drugs. To date, the etiology is not well understood and individual susceptibility still remains unknown. Amiodarone, chlorpromazine, amitriptyline, and trimipramine are classified lysosomotropic as well as photosensitizing, however, they fail to trigger rash and pruritic papules in all individuals. Lysosomotropism is a common charcteristic of various...
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#1Andrey Sivkov (MSMU: Sechenov University)
#2N P Chernus (MSMU: Sechenov University)H-Index: 1
Last. Tamara Savina (MSMU: Sechenov University)
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Background null To determine the effect of genetic polymorphism of drug transporters on the efficacy of treatment with Rosuvastatin, Atorvastatin and Simvastatin in patients with hyperlipidemia. null Methods null The study consists of 180 patients, aged 40-75 years, with hyperlipidemia. All patients were divided into two equal groups: patients with different SLCO1B1 (521CC, 521CT and 521TT) and MDR1 (3435CC, 3435TC and 3435TT) genotypes. Each group was divided into rosuvastatin-treated, atorvast...
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#1Afaf El-Ansary (KSU: King Saud University)H-Index: 26
#2Manan A. Alhakbany (KSU: King Saud University)H-Index: 4
Last. Laila Y. Al-Ayadhi (KSU: King Saud University)H-Index: 32
view all 7 authors...
BACKGROUND Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and restricted and repetitive behaviors. Neuroinflammation and abnormal lipid mediators have been identified in multiple investigations as an acknowledged etiological mechanism of ASD that can be targeted for therapeutic intervention. METHODS In this study, multiple regression and combined receiver operating characteristic (ROC) curve analyses were used to determine the r...
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