Neuroscience

Receptor

Interneuron

Biology

Motor learning

Neuropeptide

Inhibitory postsynaptic potential

Psychology

Somatostatin

Stimulation

Primary motor cortex

Motor cortex

Vasoactive intestinal peptide

Synaptic plasticity

Neuroplasticity

Biochemistry

Neuron

Adler et al. reveal mechanisms underlying learning-dependent sequential activation of pyramidal neurons in the primary motor cortex. SST-expressing interneurons and CaMKII-dependent synaptic plasticity control the establishment of sequential activity during motor training and prevent the interference from new learning.

Somatostatin-Expressing Interneurons Enable and Maintain Learning-Dependent Sequential Activation of Pyramidal Neurons