Optimization and repeatability of multipool chemical exchange saturation transfer MRI of the prostate at 3.0 T.

Published on Oct 1, 2019in Journal of Magnetic Resonance Imaging3.954
· DOI :10.1002/JMRI.26690
Vincent Evans2
Estimated H-index: 2
(UCL: University College London),
F. J. Torrealdea9
Estimated H-index: 9
(UCL: University College London)
+ 8 AuthorsDavid Atkinson68
Estimated H-index: 68
(UCL: University College London)
Sources
Abstract
BACKGROUND: Chemical exchange saturation transfer (CEST) can potentially support cancer imaging with metabolically derived information. Multiparametric prostate MRI has improved diagnosis but may benefit from additional information to reduce the need for biopsies. PURPOSE: To optimize an acquisition and postprocessing protocol for 3.0 T multipool CEST analysis of prostate data and evaluate the repeatability of the technique. STUDY TYPE: Prospective. SUBJECTS: Five healthy volunteers (age range: 24-47 years; median age: 28 years) underwent two sessions (interval range: 7-27 days; median interval: 20 days) and two biopsy-proven prostate cancer patients were evaluated once. Patient 1 (71 years) had a Gleason 3 + 4 transition zone (TZ) tumor and patient 2 (55 years) had a Gleason 4 + 3 peripheral zone (PZ) tumor. FIELD STRENGTH: 3.0 T. Sequences run: T2 -weighted turbo-spin-echo (TSE); diffusion-weighted imaging; CEST; WASABI (for B0 determination). ASSESSMENT: Saturation, readout, and fit-model parameters were optimized to maximize in vivo amide and nuclear Overhauser effect (NOE) signals. Repeatability (intrasession and intersession) was evaluated in healthy volunteers. Subsequently, preliminary evaluation of signal differences was made in patients. Regions of interest were drawn by two post-FRCR board-certified readers, both with over 5 years of experience in multiparametric prostate MRI. STATISTICAL TESTS: Repeatability was assessed using Bland-Altman analysis, coefficient of variation (CV), and 95% limits of agreement (LOA). Statistical significance of CEST contrast was calculated using a nonparametric Mann-Whitney U-test. RESULTS: The optimized saturation scheme was found to be 60 sinc-Gaussian pulses with 40 msec pulse duration, at 50% duty-cycle with continuous-wave pulse equivalent B1 power (B1CWPE ) of 0.92 μT. The magnetization transfer (MT) contribution to the fit-model was centered at -1.27 ppm. Intersession coefficients of variation (CVs) of the amide, NOE, and magnetization transfer (MT) and asymmetric magnetization transfer ratio (MTRasym ) signals of 25%, 23%, 18%, and 200%, respectively, were observed. Fit-metric and MTRasym CVs agreed between readers to within 4 and 10 percentage points, respectively. DATA CONCLUSION: Signal differences of 0.03-0.10 (17-43%) detectable depending upon pool, with MT the most repeatable (signal difference of 17-22% detectable). LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:1238-1250.
📖 Papers frequently viewed together
14 Citations
39 Citations
65 Citations
References38
Newest
#1Shu Zhang (UTSW: University of Texas Southwestern Medical Center)H-Index: 4
#2Stephen J. Seiler (UTSW: University of Texas Southwestern Medical Center)H-Index: 8
Last. Elena VinogradovH-Index: 22
view all 8 authors...
Purpose CEST MRI for breast lesion characterization is promising. However, artifacts are prone to develop in breast CEST imaging due to strong lipid signals. The aims of the study are: 1) to develop and validate the CEST-Dixon imaging sequence for simultaneous water-fat separation and B0 mapping; 2) use the CEST-Dixon method to characterize suspicious lesions in patients undergoing percutaneous biopsy. Methods The gradient-echo multi-echo Dixon acquisition is used to create fat-free CEST and B0 ...
19 CitationsSource
#1Tristan Barrett (University of Cambridge)H-Index: 17
#1Tristan Barrett (University of Cambridge)H-Index: 36
Last. Ferdia A. Gallagher (University of Cambridge)H-Index: 34
view all 12 authors...
Objective To evaluate diffusion kurtosis imaging (DKI) and magnetisation transfer imaging (MTI) compared to standard MRI for prostate cancer assessment in a re-biopsy population.
25 CitationsSource
PURPOSE: To introduce and evaluate an image registration technique for robust quantification of CEST acquisitions corrupted by motion. METHODS: The proposed iterative algorithm exploits a low-rank approximation of the z-spectrum (LRAZ), to gradually separate the contrast variation due to saturation at different off-resonance frequencies and accompanying motion. This registration method was first tested in a creatine CEST analysis of a phantom with simulated rigid motion. Subsequently, creatine C...
10 CitationsSource
#1Veeru Kasivisvanathan (London North West Healthcare NHS Trust)H-Index: 4
#1Veeru Kasivisvanathan (Royal Free London NHS Foundation Trust)H-Index: 4
Last. Caroline M. Moore (London North West Healthcare NHS Trust)H-Index: 34
view all 41 authors...
Abstract Background Multiparametric magnetic resonance imaging (MRI), with or without targeted biopsy, is an alternative to standard transrectal ultrasonography–guided biopsy for prostate-cancer detection in men with a raised prostate-specific antigen level who have not undergone biopsy. However, comparative evidence is limited. Methods In a multicenter, randomized, noninferiority trial, we assigned men with a clinical suspicion of prostate cancer who had not undergone biopsy previously to under...
964 CitationsSource
#1Peter C.M. van Zijl (ICSCI: Kennedy Krieger Institute)H-Index: 109
#2Wilfred W. Lam (Sunnybrook Research Institute)H-Index: 12
Last. Greg J. Stanisz (Medical University of Lublin)H-Index: 41
view all 5 authors...
Abstract Magnetization Transfer Contrast (MTC) and Chemical Exchange Saturation Transfer (CEST) experiments measure the transfer of magnetization from molecular protons to the solvent water protons, an effect that becomes apparent as an MRI signal loss (“saturation”). This allows molecular information to be accessed with the enhanced sensitivity of MRI. In analogy to Magnetic Resonance Spectroscopy (MRS), these saturation data are presented as a function of the chemical shift of participating pr...
102 CitationsSource
#1Andriy Fedorov (Brigham and Women's Hospital)H-Index: 26
#2Mark Vangel (Harvard University)H-Index: 70
Last. Fiona M. FennessyH-Index: 35
view all 4 authors...
ObjectivesThe aim of this study was to evaluate the repeatability of a region of interest (ROI) volume and mean apparent diffusion coefficient (ADC) in standard-of-care 3 T multiparametric magnetic resonance imaging (mpMRI) of the prostate obtained with the use of endorectal coil.Materials and Metho
29 CitationsSource
#1Iris Yuwen Zhou (Harvard University)H-Index: 19
#2Enfeng Wang (Zhengzhou University)H-Index: 11
Last. Phillip Zhe Sun (Harvard University)H-Index: 33
view all 6 authors...
Chemical Exchange Saturation Transfer (CEST) MRI is sensitive to dilute metabolites with exchangeable protons, allowing tissue characterization in diseases such as acute stroke and tumor. CEST quantification using multi-pool Lorentzian fitting is challenging due to its strong dependence on image signal-to-noise ratio (SNR), initial values and boundaries. Herein we proposed an Image Downsampling Expedited Adaptive Least-squares (IDEAL) fitting algorithm that quantifies CEST images based on initia...
40 CitationsSource
#1Hashim U. Ahmed (UCL: University College London)H-Index: 62
#2Ahmed El-Shater Bosaily (UCL: University College London)H-Index: 6
Last. Mark Emberton (UCL: University College London)H-Index: 80
view all 14 authors...
Summary Background Men with high serum prostate specific antigen usually undergo transrectal ultrasound-guided prostate biopsy (TRUS-biopsy). TRUS-biopsy can cause side-effects including bleeding, pain, and infection. Multi-parametric magnetic resonance imaging (MP-MRI) used as a triage test might allow men to avoid unnecessary TRUS-biopsy and improve diagnostic accuracy. Methods We did this multicentre, paired-cohort, confirmatory study to test diagnostic accuracy of MP-MRI and TRUS-biopsy agai...
1,256 CitationsSource
#1Patrick Schuenke (DKFZ: German Cancer Research Center)H-Index: 9
#2Johannes Windschuh (DKFZ: German Cancer Research Center)H-Index: 15
Last. Moritz Zaiss (DKFZ: German Cancer Research Center)H-Index: 28
view all 6 authors...
Purpose Together with the development of MRI contrasts that are inherently small in their magnitude, increased magnetic field accuracy is also required. Hence, mapping of the static magnetic field (B0) and the excitation field (B1) is not only important to feedback shim algorithms, but also for postprocess contrast-correction procedures. Methods A novel field-inhomogeneity mapping method is presented that allows simultaneous mapping of the water shift and B1 (WASABI) using an off-resonant rectan...
56 CitationsSource
#1Lori R. Arlinghaus (VUMC: Vanderbilt University Medical Center)H-Index: 4
#1Lori R. Arlinghaus (VUMC: Vanderbilt University Medical Center)H-Index: 23
Last. Thomas E. Yankeelov (University of Texas at Austin)H-Index: 52
view all 6 authors...
: Quantitative magnetization transfer magnetic resonance imaging provides a means for indirectly detecting changes in the macromolecular content of tissue noninvasively. A potential application is the diagnosis and assessment of treatment response in breast cancer; however, before quantitative magnetization transfer imaging can be reliably used in such settings, the technique's reproducibility in healthy breast tissue must be established. Thus, this study aims to establish the reproducibility of...
9 CitationsSource
Cited By8
Newest
#1Nicola Schieda (Ottawa Hospital)H-Index: 28
#2Christopher S. Lim (Sunnybrook Health Sciences Centre)H-Index: 11
Last. Baris TurkbeyH-Index: 76
view all 9 authors...
: Prostate MRI is reported in clinical practice using the Prostate Imaging and Data Reporting System (PI-RADS). PI-RADS aims to standardize, as much as possible, the acquisition, interpretation, reporting, and ultimately the performance of prostate MRI. PI-RADS relies upon mainly subjective analysis of MR imaging findings, with very few incorporated quantitative features. The shortcomings of PI-RADS are mainly: low-to-moderate interobserver agreement and modest accuracy for detection of clinical...
8 CitationsSource
#1Kai Herz (MPG: Max Planck Society)H-Index: 8
#2Sebastian Mueller (MPG: Max Planck Society)H-Index: 5
Last. Moritz Zaiss (MPG: Max Planck Society)H-Index: 28
view all 15 authors...
PURPOSE As the field of CEST grows, various novel preparation periods using different parameters are being introduced. At the same time, large, multisite clinical studies require clearly defined protocols, especially across different vendors. Here, we propose a CEST definition standard using the open Pulseq format for a shareable, simple, and exact definition of CEST protocols. METHODS We present the benefits of such a standard in three ways: (1) an open database on GitHub, where fully defined, ...
Source
#1Steffen Goerke (DKFZ: German Cancer Research Center)H-Index: 14
#2Johannes Breitling (DKFZ: German Cancer Research Center)H-Index: 5
Last. Peter Bachert (DKFZ: German Cancer Research Center)H-Index: 13
view all 8 authors...
PURPOSE The value of relaxation-compensated amide proton transfer (APT) and relayed nuclear Overhauser effect (rNOE) chemical exchange saturation transfer (CEST)-MRI has already been demonstrated in various neuro-oncological clinical applications. Recently, we translated the approach from 7T to a clinically relevant magnetic field strength of 3T. However, the overall acquisition time was still too long for a broad application in the clinical setting. The aim of this study was to establish a shor...
Source
#1Clarissa Gillmann (DKFZ: German Cancer Research Center)H-Index: 6
#2Gabor Pajor (DKFZ: German Cancer Research Center)
Last. Michael Baumann (DKFZ: German Cancer Research Center)H-Index: 20
view all 8 authors...
The second international DKFZ Conference on Cancer Prevention (CCP2020) organized by the German Cancer Research Center (DKFZ) was held as a virtual event on September 17-18, 2020. The event gathered experts on cancer prevention from around the world with the aim of generating a stimulating interchange of opinions between clinicians and basic researchers working in the field. The talks and posters of the conference fueled exciting discussions and debates about the state of the art of cancer preve...
Source
#1Lebina S. Kakkar (UCL: University College London)H-Index: 2
#2Muhammad Usman (UCL: University College London)H-Index: 68
Last. David Atkinson (UCL: University College London)H-Index: 68
view all 5 authors...
Multi-parametric MRI is increasingly used for prostate cancer detection. Improving information from current sequences, such as T2-weighted and diffusion-weighted (DW) imaging, and additional sequences, such as magnetic resonance spectroscopy (MRS) and chemical exchange saturation transfer (CEST), may enhance the performance of multi-parametric MRI. The majority of these techniques are sensitive to B0-field variations and may result in image distortions including signal pile-up and stretching (ec...
Source
#1Johannes BreitlingH-Index: 5
#2Jan Eric Meissner (DKFZ: German Cancer Research Center)H-Index: 10
Last. Peter BachertH-Index: 9
view all 7 authors...
: Dual-frequency irradiation chemical exchange saturation transfer (dualCEST) allows imaging of endogenous bulk mobile proteins by selectively measuring the intramolecular spin diffusion. The resulting specificity to changes in the concentration, molecular size, and folding state of mobile proteins is of particular interest as a marker for neurodegenerative diseases and cancer. Until now, application of dualCEST in clinical trials was prevented by the inherently small signal-to-noise ratio and t...
1 CitationsSource
#1Ayan Debnath (IITD: Indian Institute of Technology Delhi)H-Index: 4
#2Hari Hariharan (UPenn: University of Pennsylvania)H-Index: 26
Last. Anup Singh (AIIMS, New Delhi)H-Index: 27
view all 5 authors...
To mitigate the effect of magnetization transfer (MT) from glutamate-weighted chemical exchange saturation transfer (GluCEST) contrast in healthy human brain and its demonstration in a rat brain tumor model. GluCEST data was acquired from six healthy human volunteers at 7T and on a rat brain with tumor at 9.4 T. Single voxel proton magnetic resonance spectroscopy (1HMRS) data was acquired from three human volunteers. The magnetic resonance imaging protocol included CEST data acquisition at multi...
6 CitationsSource
#1Anup Singh (AIIMS, New Delhi)H-Index: 27
#2Ayan Debnath (IITD: Indian Institute of Technology Delhi)H-Index: 4
Last. Ravinder Reddy (UPenn: University of Pennsylvania)H-Index: 66
view all 7 authors...
The current study aims to evaluate the feasibility of creatine (Cr) chemical exchange saturation transfer (CEST)-weighted MRI at 7 T in the human brain by optimizing the saturation pulse parameters and computing contrast using a Z-spectral fitting approach. The Cr-weighted (Cr-w) CEST contrast was computed from phantoms data. Simulations were carried out to obtain the optimum saturation parameters for Cr-w CEST with lower contribution from other brain metabolites. CEST-w images were acquired fro...
9 CitationsSource