Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes

Neuropsychiatric disorders, type 2 diabetes (T2D) and obesity are major public health concerns that have been increasingly proposed to be intimately connected. T2D and obesity are associated with increased risk of neuropsychiatric and mood disorders, including diminished cognitive performance, and increased rates of depression, anxiety and dementia. More recently, molecular connections between depressive disorder, T2D and obesity have been...