Internal medicine

Adverse effect

Virus

Gastroenterology

Immunology

Hepatitis C virus

Hepatitis C

Tolerability

Hepacivirus

Liver transplantation

Transplantation

Medicine

Hepatology

Direct‐acting antiviral (DAA) therapy has altered the frequency and outcome of liver transplantation (LT) for hepatitis C virus (HCV). The high efficacy and tolerability of DAA therapy has also created a rationale for utilizing HCV‐viremic (HCV‐RNA–positive) donors, including into HCV‐negative recipients. We examined trends in frequency of organ utilization and graft survival in recipients of HCV‐viremic donors (HCV‐RNA positive as measured by nucleic acid testing [NAT]). Data were collected from the Scientific Registry of Transplant Recipients (SRTR) on adult patients who underwent a primary, single‐organ, deceased donor LT from January 1, 2008 to January 31, 2018. Outcomes of HCV‐negative transplant recipients (R – ) who received an allograft from donors who were HCV‐RNA positive (DNAT + ) were compared to outcomes for R – patients who received organs from donors who were HCV‐RNA negative (DNAT – ). There were 11,270 DNAT – /R – ; 4,748 DNAT – /R + ; 87 DNAT + /R – ; and 753 DNAT + /R + patients, with 2‐year graft survival similar across all groups: DNAT – /R – 88%; DNAT – /R + 88%; DNAT + /R – 86%; and DNAT + /R + 90%. Additionally, there were 2,635 LTs using HCV antibody‐positive donors (DAb + ): 2,378 DAb + /R + and 257 DAb + /R – . The annual number of DAb + /R – transplants increased from seven in 2008 to 107 in 2017. In the post‐DAA era, graft survival improved for all recipients, with 3‐year survival of DAb + /R – patients and DAb + /R + patients increasing to 88% from 79% and to 85% from 78%, respectively. Conclusion: The post‐DAA era has seen increased utilization of HCV‐viremic donor livers, including HCV‐viremic livers into HCV‐negative recipients. Early graft outcomes are similar to those of HCV‐negative recipients. These results support utilization of HCV‐viremic organs in selected recipients both with and without HCV infection.

Increasing Utilization and Excellent Initial Outcomes Following Liver Transplant of Hepatitis C Virus (HCV)‐Viremic Donors Into HCV‐Negative Recipients: Outcomes Following Liver Transplant of HCV‐Viremic Donors