Systemic disease

Rheumatology

Etiology

Serology

Dermatology

Rheumatoid arthritis

Immunology

Autoantibody

SSS*

Internal medicine

Immunopathology

Lupus erythematosus

Medicine

Disease

Antibody

Open Access Rheumatology Research and Reviews

Sjogren's syndrome and systemic lupus erythematosus: links and risks Sandra Gofinet Pasoto,1,2 Victor Adriano de Oliveira Martins,1 Eloisa Bonfa1 1Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil; 2Laboratory Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, Sao Paulo, Brazil Abstract: Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) may coexist, and they are chronic complex disorders, with an autoimmune background, multifactorial etiology, multiple circulating autoantibodies, and variable prognosis. The prominent feature of SS is the impairment of the lacrimal and salivary glands leading to sicca symptoms. This disease may be classified as primary Sjögren's syndrome (pSS), or secondary Sjögren's syndrome (sSS) since it is often associated to other autoimmune disorders, principally SLE, rheumatoid arthritis, and systemic sclerosis. Systematic reviews and meta-analyses show an sSS prevalence in SLE patients of about 14%–17.8%. Herein, we updated important aspects of the clinical association between SLE and sSS through a narrative review of the PubMed database in the last 5 years (from July 2013 to October 2018) with the terms "Sjogren syndrome and systemic lupus erythematosus". The following aspects are addressed: the classification criteria for sSS; differences and similarities between SLE and pSS regarding demographic, clinical, and serological characteristics (including new autoantibodies), as well as comorbidities; the etiopathogenic links between SLE and pSS (including genetic and environmental factors, B-cell activation, and autoantibodies); the predictive factors for sSS onset in SLE patients; the ocular and oral involvements due to sSS in SLE; and the main distinctive demographic, clinical, and serological features of SLE with and without associated SS. Keywords: systemic lupus erythematosus, primary Sjögren's syndrome, secondary Sjögren's syndrome, polyautoimmunity, anti-Ro, anti-SSA, autoantibodies, pathogenesis

&lt;p&gt;Sj&amp;ouml;gren&amp;#39;s syndrome and systemic lupus erythematosus: links and risks&lt;/p&gt;

&lt;p&gt;Sj&amp;ouml;gren&amp;#39;s syndrome and systemic lupus erythematosus: links and risks&lt;/p&gt;

<p>Sjögren's syndrome and systemic lupus erythematosus: links and risks</p>