Biology

Ovarian tissue cryopreservation

Surgery

Transplantation

Ovarian tissue

Environmental health

Fertility preservation

Genetics

Pediatrics

Fertility

Population

Internal medicine

Obstetrics

Gynecology

Girl

Medicine

Thalassemia

Ovary

Pregnancy

Minerva Obstetrics and Gynecology

Ovarian tissue removed from a 9-year-old girl suffering from thalassemia was kept deep-frozen for 14 years before being transplanted back to the now adult woman. Subsequently, she conceived following IVF treatment and delivered a healthy baby where the oocyte derived from the transplanted tissue. This is the first woman worldwide to have a baby where the ovarian tissue was frozen pre-pubertally and expand the therapeutic options for rare genetic diseases like thalassemia and girls who suffer from childhood cancer.

Successful pregnancy in a woman previously suffering from β-thalassemia following transplantation of ovarian tissue cryopreserved before puberty