Type 2 Diabetes Mellitus

Type 2 diabetes

Steatosis

Endocrinology

Magnetic resonance cholangiopancreatography

Pancreatitis

Radiology

Intra-Abdominal Fat

Insulin resistance

Internal medicine

Visceral fat

Medicine

Obesity

Gastroenterology

Endoscopic retrograde cholangiopancreatography

Adipose tissue

Magnetic resonance imaging

Diabetes mellitus

Pancreas

Objective The aim of this study was to determine the association of the pancreatic steatosis with obesity, chronic pancreatitis (CP), and type 2 diabetes mellitus. Methods Patients (n = 118) were retrospectively identified and categorized into no CP (n = 60), mild (n = 21), moderate (n = 27), and severe CP (n = 10) groups based on clinical history and magnetic resonance cholangiopancreatography using the Cambridge classification as the diagnostic standard. Visceral and subcutaneous compartments were manually segmented, and fat tissue was quantitatively measured on axial magnetic resonance imaging. Results Pancreatic fat fraction showed a direct correlation with fat within the visceral compartment ( r = 0.54). Patients with CP showed higher visceral fat ( P = 0.01) and pancreatic fat fraction ( P &lt; 0.001): mild, 24%; moderate, 23%; severe CP, 21%; no CP group, 15%. Patients with type 2 diabetes mellitus showed higher pancreatic steatosis ( P = 0.03) and higher visceral ( P = 0.007) and subcutaneous fat ( P = 0.004). Interobserver variability of measuring fat by magnetic resonance imaging was excellent ( r ≥ 0.90–0.99). Conclusions Increased visceral adipose tissue has a moderate direct correlation with pancreatic fat fraction. Chronic pancreatitis is associated with higher pancreatic fat fraction and visceral fat. Type 2 diabetes mellitus is associated with higher pancreatic fat fraction and visceral and subcutaneous adiposity.

Association of Pancreatic Steatosis With Chronic Pancreatitis, Obesity, and Type 2 Diabetes Mellitus