Papers 7,358
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#1James J. Doyle (Scott & White Hospital)
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OBJECTIVES The incidence of pancreatic cancer is age dependent. Ninety percent of new diagnoses occur in patients older than 55 years. Despite the association with age and cancer, elderly patients are historically underrepresented in clinical trials. Thus, optimal management of elderly patients has a lack of data. The purpose of this retrospective study was to investigate the outcomes of palliative chemotherapy in elderly patients with pancreatic cancer compared with supportive care alone. METHO...
#1Xi JiangH-Index: 8
#2Ji-Yao GuoH-Index: 1
Last. Zhuan LiaoH-Index: 26
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#1Nour El-Mais (Lebanese American University)H-Index: 1
#2Isabelle Fakhoury (Lebanese American University)H-Index: 6
Last. Mirvat El-Sibai (Lebanese American University)H-Index: 23
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OBJECTIVES Pancreatic cancer is one of the most aggressive solid cancers and the fourth leading cause of cancer death in men and women. We previously showed that arginine depletion, using arginase I [HuArgI(Co)-PEG5000], selectively triggers cell death by autophagy in PANC-1 pancreatic cancer cells. The mechanism of action of [HuArgI(Co)-PEG5000], however, has remained poorly understood. In this study, we investigated the effects of arginine depletion on PANC-1 cell migration, adhesion, and inva...
#1Patrick TwohigH-Index: 3
#2Enrique de-MadariaH-Index: 20
Last. Dalbir S. SandhuH-Index: 16
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OBJECTIVES Quantify the risk of drug-induced pancreatitis (DIP) from angiotensin-converting enzyme inhibitors (ACEis) and 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors (statins). METHODS Retrospective cohort analysis using IBM Explorys (1999-2019), a pooled, deidentified clinical database of more than 63 million patients across the United States. Odds ratios were calculated to determine the risk of DIP from ACEi, statins, and both medications together. χ2 testing assessed the relationship...
#1Li ZhouH-Index: 1
#2Jun LuH-Index: 8
Last. Junchao GuoH-Index: 19
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Objective null Thus far, expression, clinicopathologic, and prognostic implication of small mothers against decapentaplegic 7 (Smad7), matrix metalloproteinase 2 (MMP2), and matrix metalloproteinase 9 (MMP9) in pancreatic ductal adenocarcinoma (PDAC) were rarely investigated or controversial. null Methods null Expression of Smad7, MMP2, and MMP9 was detected using immunohistochemistry in tissue microarrays based on 322 patients with curatively resected PDAC. Their expression pattern, clinicopath...
#2Tao Huang (CQMU: Chongqing Medical University)
Last. Jun DuanH-Index: 13
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OBJECTIVE The aim of the study was to identify risk factors associated with the failure of noninvasive ventilation (NIV) in patients with severe acute pancreatitis (SAP). METHODS Patients who received NIV as a first-line therapy because of acute respiratory failure caused by SAP were enrolled. RESULTS A total of 133 patients were enrolled. Of the patients, 32 (24%) experienced NIV failure. Male sex (odds ratio [OR], 4.25; 95% confidence interval [CI], 1.48-12.22), older age (OR, 1.04; 95% CI, 1....
#1Masanari SekineH-Index: 3
#2Akira TanakaH-Index: 34
Last. Hirosato MashimaH-Index: 20
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OBJECTIVE The concept of early chronic pancreatitis (ECP) and its diagnostic criteria were first proposed by Japan, using endoscopic ultrasonography (EUS) findings for diagnosis. However, these findings have not been supported by pathological findings. We aimed to examine the association between the EUS and pathological findings of the same area of the pancreas. METHODS In 12 patients who underwent pancreaticoduodenectomy for distal bile duct cancer without accompanying pancreatitis, a comparati...
#1Hirokazu KimuraH-Index: 1
#2Alison P. KleinH-Index: 68
Last. Nicholas J. RobertsH-Index: 21
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ABSTRACT CDKN2A is cell cycle negative regulator, and the role of CDKN2A in the development of pancreatic ductal adenocarcinoma, which continues to be a lethal cancer, is well-established. Somatic loss of CDKN2A is considered one of the major drivers of pancreatic tumorigenesis. CDKN2A gene is one of the pancreatic cancer susceptibility gene; in addition to melanoma, pathogenic germline CDKN2A variants have been identified in up to 3.3% patients with pancreatic ductal adenocarcinoma depending on...
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