Pancreas
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#1Grace M. Lee (Harvard University)H-Index: 54
#2Daniel H. KimH-Index: 62
Last. Jennifer Y. WoH-Index: 26
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OBJECTIVES We evaluated the outcomes of metastatic pancreatic cancer (MPC) patients who underwent liver metastases (LMs)-directed ablative radiotherapy (RT) and sought to characterize patients with more favorable prognosis. METHODS A retrospective analysis of 76 MPC patients who underwent ablative RT (median dose, 50 Gy) to LM at 3 academic centers between 2008 and 2018 was performed. Endpoints were local control (LC), progression-free survival, and overall survival (OS) since RT. RESULTS Median...
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Objectives Exocrine pancreatic insufficiency is a frequent and clinically relevant complication of pancreatic cancer probably secondary to pancreatic duct obstruction. We aimed at evaluating the impact of endoscopic pancreatic drainage on pancreatic function in patients with unresectable pancreatic cancer. Methods A double-blind, prospective, randomized, single-center, interventional study was designed. Patients undergoing endoscopic retrograde cholangiopancreatography for jaundice secondary to ...
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#1Masanori Kobayashi (Tokyo Medical and Dental University)
#2Akashi FujitaH-Index: 4
Last. Shomei RyozawaH-Index: 17
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OBJECTIVES Early detection of pancreatic cancer is notoriously difficult. A novel cancer diagnostic method using the ability of nematodes to detect odor of urine samples has been developed (N-NOSE). This method has a high sensitivity and specificity for various cancers; however, it has not yet been verified in pancreatic cancer. We examined the usefulness of this method to aid early diagnosis of pancreatic cancer in a cancer center. METHODS We collected urine samples and clinical data from patie...
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#1Raffaele Pezzilli (University of Milan)H-Index: 41
#2Stefano CentanniH-Index: 28
Last. Alessandra BarassiH-Index: 21
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OBJECTIVES Gastrointestinal manifestations of coronavirus disease 19 (COVID-19) have been well established, but pancreatic involvement is under debate. Our aims were to evaluate the presence of acute pancreatitis in COVID-19 patients and to assess the frequency of pancreatic hyperenzymemia. METHODS From April 1, 2020, to April 30, 2020, 110 consecutive patients (69 males, 41 females; mean age, 63.0 years; range, 24-93 years) met these criteria and were enrolled in the study. The clinical data an...
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#1Marina Baretti (The Ohio State University Wexner Medical Center)
#2Qingfeng ZhuH-Index: 12
Last. Ana De Jesus-AcostaH-Index: 14
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OBJECTIVES The aim of this study was to characterize the tumor microenvironment of patients with gastroenteropancreatic neuroendocrine tumors relative to progression-free survival (PFS). METHODS Immune profiling for CD3, CD8, programmed death-1/programmed death-ligand 1, and indoleamine 2,3-dioxygenase expression in 2 cohorts of gastroenteropancreatic neuroendocrine tumors: patients with short PFS (<4 years, n = 12) versus long PFS (≥4 years, n = 14) after surgery. Immune infiltrates in the tumo...
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#1Antti Turunen (UH: University of Helsinki)
#2Antti KuulialaH-Index: 10
Last. Krista KuulialaH-Index: 8
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OBJECTIVES Clinical practice lacks biomarkers to predict the severity of acute pancreatitis (AP). We studied if intracellular signaling of circulating leukocytes could predict persistent organ dysfunction (OD) and secondary infections in AP. METHODS A venous blood sample was taken from 174 patients with AP 72 hours or less from onset of symptoms and 31 healthy controls. Phosphorylation levels (p) of appropriately stimulated signal transducer and activator of transcription 1 (STAT1), STAT6, nucle...
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#1Masahiro Shitani (Sapporo Medical University)H-Index: 5
#2Jiro OginoH-Index: 10
Last. Hiroshi NakaseH-Index: 37
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Last. Ursula FalkmerH-Index: 20
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OBJECTIVES The aim of this study was to identify patterns of palliative chemotherapy (CTh) and the associated overall survival (OS) in patients with pancreatic cancer, with specific focus on age. METHODS Between May 1, 2011, and April 30, 2016, 4260 patients were registered in the Danish Pancreatic Cancer Database. The 1715 patients receiving palliative CTh were retrieved. Age was grouped into less than 70, 70 to less than 75 and 75 years or more. RESULTS Of the 1715 patients receiving first-lin...
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#1Stephen A. Firkins (The Ohio State University Wexner Medical Center)
#2Phil A. HartH-Index: 25
Last. Somashekar G. KrishnaH-Index: 18
view all 9 authors...
OBJECTIVES There is a paucity of studies evaluating predictors of new-onset diabetes mellitus (DM) after acute pancreatitis (AP-related DM). We used a population-based database to evaluate predictors of AP-related DM. METHODS The Nationwide Readmissions Database (2010-2014) was used to identify all nondiabetic adults with an index primary diagnosis of AP. Multiple exclusions were applied to identify cohorts with and without AP-related DM. A case-control study was conducted to identify risk facto...
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#1Luis F. Lara (The Ohio State University Wexner Medical Center)H-Index: 21
#2Laura NemerH-Index: 1
Last. Somashekar G. KrishnaH-Index: 18
view all 6 authors...
OBJECTIVES Cannabis legalization has increased its use. The incidence of acute pancreatitis (AP) and severe acute pancreatitis (SAP) has also increased. In this study, data on pancreatitis were obtained from 2 states before and after cannabis legalization and compared with 2 states without legalized cannabis. METHODS Data were extracted from State Inpatient Databases from the states of Colorado and Washington before recreational cannabis legalization (2011) and after legalization (2015). Arizona...
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Top fields of study
Endocrinology
Pancreatitis
Pancreas
Pancreatic cancer
Diabetes mellitus
Medicine
Biology