Gene

Biology

GATA3

T cell

Cancer research

Mycosis fungoides

Immunology

Genetics

FOXP3

Transcriptome

Immune system

Lymphoma

Transcription factor

Cutaneous T-cell lymphoma

Medicine

Gene expression profiling

Disease

Gene expression

Pathology

Clinical Cancer Research

Cutaneous T-cell lymphomas (CTCL), encompassing a spectrum of T-cell lymphoproliferative disorders involving the skin, have collectively increased in incidence over the last 40 years. Sézary syndrome is an aggressive form of CTCL characterized by significant presence of malignant cells in both the blood and skin. The guarded prognosis for Sézary syndrome reflects a lack of reliably effective therapy, due, in part, to an incomplete understanding of disease pathogenesis.

Single-Cell Profiling of Cutaneous T-Cell Lymphoma Reveals Underlying Heterogeneity Associated with Disease Progression