Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepine

Volume: 26, Issue: 2, Pages: 121 - 128
Published: Feb 1, 2019
Abstract
Many drugs target the serotonin 2A receptor (5-HT2AR), including second-generation antipsychotics that also target the dopamine D2 receptor (D2R). These drugs often produce severe side effects due to non-selective binding to other aminergic receptors. Here, we report the structures of human 5-HT2AR in complex with the second-generation antipsychotics risperidone and zotepine. These antipsychotics effectively stabilize the inactive conformation...
Paper Details
Title
Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepine
Published Date
Feb 1, 2019
Volume
26
Issue
2
Pages
121 - 128
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