Recent advances in understanding the regulation of metalloproteinases

David Young; Matt J. Barter; David J. Wilkinson

doi:https://doi.org/10.12688/f1000research.17471.1

doi.org/10.12688/f1000research.17471.1

Recent advances in understanding the regulation of metalloproteinases

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Volume: 8, Pages: 195 - 195

Published: Feb 18, 2019

Abstract

Metalloproteinases remain important players in arthritic disease, in part because members of this large enzymatic family, namely matrix metalloproteinase-1 (MMP-1) and MMP-13, are responsible for the irreversible degradation of articular cartilage collagen. Although direct inhibition of MMPs fell out of vogue with the initial clinical disappointment of the first generation of compounds, interest in other mechanisms that control these...

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Paper Details

Title

Recent advances in understanding the regulation of metalloproteinases

DOI

doi.org/10.12688/f1000research.17471.1

Published Date

Feb 18, 2019

Journal

F1000Research

Volume

8

Pages

195 - 195

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