New sesquiterpenoid glycoside from the rhizomes of Atractylodes lancea

Published on Apr 1, 2020in Natural Product Research2.158
· DOI :10.1080/14786419.2018.1553170
Liping Long3
Estimated H-index: 3
(SPU: Shenyang Pharmaceutical University),
Lushan Wang1
Estimated H-index: 1
(SPU: Shenyang Pharmaceutical University)
+ 2 AuthorsHuiyuan Gao12
Estimated H-index: 12
(SPU: Shenyang Pharmaceutical University)
Sources
Abstract
AbstractSix sesquiterpenoids and four lignans (1–10) were isolated from the n-BuOH extract of the rhizomes of Atractylodes lancea. Among them, the new sesquiterpenoid glycoside named (4 R, 5S, 7R)-hinesolone-11-O-β-ᴅ-glucopyranoside (1), along with three known compounds (2–4) were first obtained from this genus. All the isolates were elucidated by spectroscopic analyses and chemical methods, and the absolute configurations were assigned by electronic circular dichroism spectroscopy technique. In addition, the cytotoxic bioassay of compound 1 was evaluated and results showed it had no significant antitumor activity against human cancer cell lines MCF-7, HepG-2 and Hela.
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