Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis

Brain14.50
Volume: 142, Issue: 3, Pages: 586 - 605
Published: Jan 28, 2019
Abstract
As clinical evidence supports a negative impact of dysfunctional energy metabolism on the disease progression in amyotrophic lateral sclerosis, it is vital to understand how the energy metabolic pathways are altered and whether they can be restored to slow disease progression. Possible approaches include increasing or rerouting catabolism of alternative fuel sources to supplement the glycolytic and mitochondrial pathways such as glycogen, ketone...
Paper Details
Title
Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis
Published Date
Jan 28, 2019
Journal
Volume
142
Issue
3
Pages
586 - 605
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