Internal medicine

Somatic hypermutation

Chromosome abnormality

Biology

Gene

Oncology

Antibody

Immunology

Chronic lymphocytic leukemia

IGHV@

B cell

Leukemia

Chromosome

Karyotype

Genetics

Medicine

Blood

Complex karyotype defined by the presence of ≥3 chromosomal abnormalities should not be axiomatically considered unfavorable in CLL. High cytogenetic complexity with ≥5 chromosomal aberrations emerges as prognostically adverse, independently of other biomarkers.

Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations, and clinical impact