Enzymatic Reconstitution and Biosynthetic Investigation of the Lasso Peptide Fusilassin

Volume: 141, Issue: 1, Pages: 290 - 297
Published: Dec 27, 2018
Abstract
Lasso peptides are a class of ribosomally synthesized and post-translationally modified natural product which possess a unique lariat knot conformation. The low entropy "threaded" conformation endows lasso peptides with considerable resistance to heat and proteolytic degradation, which are attractive properties for the development of peptide-based therapeutics. Despite their discovery nearly 30 years ago, the molecular mechanism underlying lasso...
Paper Details
Title
Enzymatic Reconstitution and Biosynthetic Investigation of the Lasso Peptide Fusilassin
Published Date
Dec 27, 2018
Volume
141
Issue
1
Pages
290 - 297
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