CDK8 as a therapeutic target for cancers and recent developments in discovery of CDK8 inhibitors
Abstract
Cyclin-dependent kinases 8 (CDK8) regulates transcriptional process via associating with the mediator complex or phosphorylating transcription factors (TF). Overexpression of CDK8 has been observed in various cancers. It mediates aberrant activation of Wnt/β-catenin signaling pathway, which is initially recognized and best studied in colorectal cancer (CRC). CDK8 acts as an oncogene and represents a potential target for developing novel CDK8...
Paper Details
Title
CDK8 as a therapeutic target for cancers and recent developments in discovery of CDK8 inhibitors
Published Date
Feb 1, 2019
Volume
164
Pages
77 - 91
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