559: First trimester MMP-8 profiles vary among women who smoke cigarettes, electronic-cigarettes and cannabis

Prenatal exposures to tobacco smoke, e-cigarette (ecig) vapor, and cannabis smoke is increasing and are more frequent in women with depressive symptoms, anxiety, and/or stress. We have previously demonstrated the inflammatory milieu is altered in populations at risk for preterm birth, with these exposures, and in women with objective assessments for stress as early as the first trimester. The purpose of the present evaluation was to assess the...