Nanomaterials

Pathology

Nanoparticle

Nanotechnology

Organic chemistry

Chemistry

Materials science

Superoxide dismutase

Biocompatibility

Antioxidant

Glutathione peroxidase

Catalase

Disease

Neurotoxicity

Parkinson's disease

Toxicity

Reactive oxygen species

Biochemistry

Medicine

Journal of the American Chemical Society

Reactive oxygen species (ROS)-mediated mitochondrial dysfunction is one of the major pathological mechanisms of Parkinson's disease. Using inorganic nanomaterials to scavenge ROS has drawn significant interest and can prevent ROS-mediated neurological disorders. We prepared uniform Cu xO nanoparticle clusters (NCs) with an average size of 65 ± 7 nm, using phenylalanine (Phe) as the structure-directing agent. These Cu xO NCs functionally mimicked the activities of peroxidase, superoxide dismutase, catalase, and glutathione peroxidase. Because they eliminated ROS, the Cu xO NCs inhibited neurotoxicity in a cellular model of Parkinson's disease and rescued the memory loss of mice with Parkinson's disease. The biocompatibility and multiple enzyme-mimicking activities of Cu xO NCs offer new opportunities for the application of NCs in biomedicine, biosensing, and biocatalysis.

Chiral Molecule-mediated Porous Cu<sub><i>x</i></sub>O Nanoparticle Clusters with Antioxidation Activity for Ameliorating Parkinson’s Disease

Chiral Molecule-mediated Porous CuxO Nanoparticle Clusters with Antioxidation Activity for Ameliorating Parkinson’s Disease

Chiral Molecule-mediated Porous Cu_xO Nanoparticle Clusters with Antioxidation Activity for Ameliorating Parkinson’s Disease