Nanomaterials

Pathology

Nanotechnology

Organic chemistry

Superoxide dismutase

Disease

Reactive oxygen species

Nanoparticle

Chemistry

Materials science

Biocompatibility

Parkinson's disease

Antioxidant

Glutathione peroxidase

Catalase

Neurotoxicity

Toxicity

Biochemistry

Medicine

Journal of the American Chemical Society

Reactive oxygen species (ROS)-mediated mitochondrial dysfunction is one of the major pathological mechanisms of Parkinson's disease. Using inorganic nanomaterials to scavenge ROS has drawn significant interest and can prevent ROS-mediated neurological disorders. We prepared uniform CuxO nanoparticle clusters (NCs) with an average size of 65 ± 7 nm, using phenylalanine (Phe) as the structure-directing agent. These CuxO NCs functionally mimicked the activities of peroxidase, superoxide dismutase, catalase, and glutathione peroxidase. Because they eliminated ROS, the CuxO NCs inhibited neurotoxicity in a cellular model of Parkinson's disease and rescued the memory loss of mice with Parkinson's disease. The biocompatibility and multiple enzyme-mimicking activities of CuxO NCs offer new opportunities for the application of NCs in biomedicine, biosensing, and biocatalysis.

Chiral Molecule-mediated Porous Cu<sub><i>x</i></sub>O Nanoparticle Clusters with Antioxidation Activity for Ameliorating Parkinson’s Disease

Chiral Molecule-mediated Porous CuxO Nanoparticle Clusters with Antioxidation Activity for Ameliorating Parkinson’s Disease

Chiral Molecule-mediated Porous Cu_xO Nanoparticle Clusters with Antioxidation Activity for Ameliorating Parkinson’s Disease